One of the most notable advancements is the introduction of Ingrezza® (valbenazine), the first FDA-approved treatment specifically designed for TD in adults.
This post explores what Ingrezza is, how it works, who it’s for, and what patients should know before starting treatment.
What Is Tardive Dyskinesia?
Tardive dyskinesia is a condition involving involuntary, repetitive body movements, often affecting the face, tongue, or limbs. It is most commonly caused by long-term use of antipsychotic medications, especially those used to treat mental health conditions like schizophrenia, bipolar disorder, and depression.
Symptoms may include:
- Grimacing, lip smacking, or tongue movements
- Rapid eye blinking
- Jerky limb or trunk movements
TD can significantly impact quality of life, affecting social interactions, self-esteem, and mental health. It is often underdiagnosed, which makes treatment access even more critical.
What Is Ingrezza?
Ingrezza (valbenazine) is a once-daily oral medication used to treat adults with tardive dyskinesia. Approved by the FDA in 2017, it works by regulating dopamine signaling in the brain—specifically by inhibiting a protein called vesicular monoamine transporter 2 (VMAT2). VMAT2 plays a role in the release of dopamine, a neurotransmitter involved in movement control.
By decreasing dopamine release in certain brain regions, Ingrezza helps reduce the abnormal movements associated with TD.
How Is Ingrezza Taken?
- Dosage: The standard dose is 80 mg once daily, although some patients may start at 40 mg to assess tolerability.
- Administration: Taken by mouth, with or without food.
- Time to Effect: Some people may notice improvement in symptoms within 2 to 4 weeks, though full benefits can take longer.
It is important to take Ingrezza consistently and not stop without consulting a healthcare provider, even if symptoms improve.
Who Should Consider Ingrezza?
Ingrezza is prescribed for adults diagnosed with tardive dyskinesia, especially when the symptoms are moderate to severe and interfere with daily functioning. It is often used in individuals who have been on long-term antipsychotic medications.
However, it may not be suitable for everyone. People with certain heart conditions, liver impairments, or those taking medications that affect the QT interval should be carefully evaluated by their healthcare provider before starting Ingrezza.
Common Side Effects
Like all medications, Ingrezza can cause side effects, though not everyone experiences them.
Common side effects include:
- Sleepiness or fatigue
- Dry mouth
- Constipation
- Balance problems
Serious but rare side effects:
- QT prolongation (a type of irregular heart rhythm)
- Worsening of psychiatric symptoms
Regular monitoring and communication with a healthcare provider can help manage any side effects that arise.
Benefits of Ingrezza
- FDA-approved specifically for tardive dyskinesia
- Once-daily dosing with or without food
- Clinically proven to reduce involuntary movements
- Well-tolerated in most patients
- May improve emotional well-being and social functioning
Cost and Accessibility
Ingrezza can be expensive without insurance, but Neurocrine Biosciences, the manufacturer, offers support programs through INBRACE Support Services, which can help with:
- Insurance navigation
- Co-pay assistance
- Patient support and education
Patients are encouraged to speak with their doctor or pharmacist about financial support options.
Key Takeaways
- Ingrezza (valbenazine) is the first FDA-approved treatment for tardive dyskinesia in adults.
- It works by reducing dopamine release through VMAT2 inhibition.
- Most patients take 80 mg once daily.
- Side effects are generally mild but should be monitored.
- Ingrezza can significantly improve quality of life for those with TD.
If you or a loved one is experiencing abnormal, involuntary movements while on antipsychotic medications, speak with your healthcare provider. Early recognition and treatment can make a meaningful difference.
Disclaimer: This article is for informational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting or stopping any medication.